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Using Dose-Escalation and -Expansion Cohort Study as Pivotal Trial for Targeted Anticancer Drug Approval

BRCA1-Associated Protein 1 and Enhancer of Zeste Homolog 2: Pathway Interaction and Therapeutic Intervention in Breast Cancer, Mesothelioma, and Lymphoma Early-phase clinical trials (EPCTs) have been ...
Journal of Epidemiology and Community Health (JECH)

10-year mortality among first-time mothers involved in family court care proceedings in England: cohort study using linked administrative hospital, mortality and family c…

Background Family court care proceedings are instigated to remove children at risk of harm from parental care. Limited ...
BMJ

Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies

6 Health and Social Research Center, Universidad de Castilla La-Mancha, Cuenca, Spain Objective To examine the predictive validity of field-based muscular strength tests in relation to incident ...
The American Journal of Managed Care

Pivotal Studies in Cardiac Prevention Highlight Power of Cohorts

The Framingham Heart Study identified key cardiovascular risk factors and developed the Framingham risk score, significantly impacting preventive cardiology. Future research in Framingham includes ...
BMJ

Joint non-linear dose–response associations of device-measured physical activity and cardiorespiratory fitness with cardiovascular disease: a cohort and Mendelian ...

Objectives To characterise the non-linear joint dose–response relationship of accelerometer-measured moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF, estimated as ...