Nanoparticles introduced into the bloodstream encounter the immune complement system, a proteolytic cascade that bridges innate surveillance and adaptive responses. Complement activation can occur via ...

Recent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene transfer—activation of the complement system. A new article in Human ...

Our immune system works around the clock to protect us from bacteria, viruses, and other harmful germs. It also helps repair damaged tissues after injuries. One of its most important defense tools is ...

Journal in the field and provides all-inclusive access to the critical pillars of human gene therapy: research, methods, and clinical applications. Recent clinical trials utilizing high doses of adeno ...

In the intricate dance of our body's defenses against harmful invaders, certain immune system proteins play pivotal roles. New research from the Bridge Institute at the USC Michelson Center for ...