A 1,563‑sample chromatin atlas reveals 16 epigenomic subgroups of AML, redefining disease classification, prognosis, and therapeutic vulnerabilities.

Learn how Organ-on-a-Chip technology supports human-relevant preclinical research and how Liver-Chip models can improve ...

Video editing Mac users can efficiently produce professional-looking content on a MacBook Air thanks to iMovie's intuitive interface and the hardware acceleration of M-series chips. Beginners benefit ...

Hematopoietic stem cells (HSCs) sustain lifelong hematopoiesis through their capacity for self-renewal and multilineage differentiation. However, the isolation and functional characterization of HSCs ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

It's no secret that Elektron's Analog Rytm is one of the best analogue drum machines on the market; in our five-star review, we praised the Rytm's sound-shaping capabilities, flexible synth ...

Installation of required libraries depends on your linux distribution, e.g., for Ubuntu: As you can see from the QC results, the data has been downsampled to 7x coverage to speed up all analyses. This ...

Assay for transposase-accessible chromatin using sequencing data (ATAC-seq) is an efficient and precise method for revealing chromatin accessibility across the genome. Most of the current ATAC-seq ...

Here we show that the histone demethylase JMJD2B is induced in endothelial cells by EndMT provoking stimuli and thereby contributes to the acquirement of a mesenchymal/smooth muscle phenotype.

Edited by Pamela A. Raymond, University of Michigan, Ann Arbor, MI, and accepted by Editorial Board Member Jeremy Nathans January 11, 2019 (received for review July 26, 2018) ...