Optimizing RNA design with AI and an Ising machine: Encoding matters

RNA has emerged as one of the most promising molecules in modern medicine, enabling advances from mRNA vaccines and gene ...

University team proposed retractable, pressurized tunnels for missions to Mars

NASA and China's national space agency plan to send crewed missions to Mars in the coming decades. Per NASA's Moon to Mars ...
PNAS

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Natural products provide the inspiration for most drugs, and marine natural products, in particular, are emerging as promising new therapeutics with new targets or mechanisms of action.
Frontiers

Strategy for Development of Site-Specific Ubiquitin Antibodies

Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent attachment of the small protein ubiquitin to a ...
C&EN

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

† Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K. ‡ Medicinal Chemistry, Department of Pharmacy and Pharmacology, ...