Abstract: The Nelder-Mead simplex method is a well-known algorithm enabling the minimization of functions that are not available in closed-form and that need not be differentiable or convex.

In recent years, the frequency of weather-related natural disasters—cyclones, torrential rains, floods—has increased as a consequence of global warming. These disasters cause billions of dollars in ...

Tensor networks enable researchers to tackle quantum physics problems previously thought to be solvable only by quantum computers. Credit: Lucy Reading-Ikkanda/Simons Foundation By applying a 1980s ...

How the proteins in our bodies bind together to form protein complexes plays a critical role in numerous cell functions—staving off diseases, for instance, or transporting ions across cell membranes.

Most people are exposed to HSV-1 in childhood. People can carry the viruses that cause oral and genital herpes without symptoms. The herpes simplex virus is incredibly common in the United States and ...

Abstract: Whereas interior point methods provide polynomial-time linear programming algorithms, the running time bounds depend on bit-complexity or condition measures that can be unbounded in the ...

The original version of this story appeared in Quanta Magazine. In 1939, upon arriving late to his statistics course at UC Berkeley, George Dantzig—a first-year graduate student—copied two problems ...

The leading approach to the simplex method, a widely used technique for balancing complex logistical constraints, can’t get any better. In 1939, upon arriving late to his statistics course at the ...

Herpes simplex virus type 2 (HSV-2) is a type of herpes virus. HSV-2 transmission through oral sex alone is rare, though it is possible to acquire the virus through sexual contact. HSV-2 causes ...

SEATTLE — It is a virus that's been ailing humans for millions of years, but to this day, there has been no absolute cure. Virologists at Fred Hutchinson Cancer Center in Seattle believe they're on ...

Background: Acyclovir-resistant mucocutaneous herpes simplex virus (HSV) infection is an uncommon problem typically seen in immunocompromised hosts. Systemic treatment options are limited. The ...